“Compulsive Sexual Behavior: Prefrontal and Limbic Volume and Interactions”

Posted on June 4, 2017, in Brain Science, Psychological, Research

Publication Information

Title: Compulsive Sexual Behavior: Prefrontal and Limbic Volume and Interactions
Publication: Human Brain Mapping
Author: Schmidt, Casper, Thaddeus Birchard, Paula Hall, Timo L. Kvamme, Laurel S. Morris, and Valerie Voon
Date: 10/26/2016



Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV).


Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry. Resting state functional MRI data using multi-echo planar sequence and independent components analysis (ME-ICA) were collected in 68 subjects (23 CSB subjects and 45 age-matched HV).


CSB subjects showed greater left amygdala gray matter volumes (small volume corrected, Bonferroni adjusted P < 0.01) and reduced resting state functional connectivity between the left amygdala seed and bilateral dorsolateral prefrontal cortex (whole brain, cluster corrected FWE P < 0.05) compared with HV.


CSB is associated with elevated volumes in limbic regions relevant to motivational salience and emotion processing, and impaired functional connectivity between prefrontal control regulatory and limbic regions. Future studies should aim to assess longitudinal measures to investigate whether these findings are risk factors that predate the onset of the behaviors or are consequences of the behaviors.

Full article here


Comments are closed.